Proven Involution of Liver Fibrosis

Hepatitis and fibrosis:
statistics
Viral hepatitis infected 5% of the population.
Even after effective antiviral therapy, the risk of fibrosis remains.
liver fibrosis of different stages is diagnosed in 7% of patients after 45 years.

Threats to liver fibrosis
progression and transition to cirrhosis
due to cirrhosis - stagnation of blood in the portal vein system
varicose veins of the esophagus
life threatening bleeding
ascites, liver failure with an irreversible scenario *
* - Bolognesi M, Di Pascoli M, Sacerdoti D. Clinical role of non-invasive assessment of portal hypertension. World J Gastroenterol. 2017;23(1):1-10.

Biirin-new hope
1.Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun Li, Li-jian Cui, Rui-xia Liu, Cheng-hong Yin. Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats. BMC Complement Altern Med. 2018; 18: 52. 2.Song X., Liu W., Xie S., Wang M., Cao G., Mao C., et al. (2013). All-transretinoic acid ameliorates bleomycin-induced lung fibrosis by downregulating the TGF-beta1/Smad3 signaling pathway in rats. Lab. Invest. 93 1219–1231.
Liver cirrhosis was considered incurable, until the molecular mechanisms of its origin and development were thoroughly studied.
International studies confirm that with a systematic approach to treatment, it is possible to regress fibrotic changes and fully restore the structure and function of the liver [1,2].
BIIRIN, a unique natural complex of plant peptides and nanoparticles of metals, has been created for the treatment of fibrosis and cirrhosis of the liver, which has proved its effectiveness.

Return of the future
BIIRIN is a natural complex
plant peptides and nanoparticles
metals which has confirmed its
efficiency in correction
fibrotic changes in the liver.

Mechanism of action
Biirin acts in a complex:
destroys the foci of cirrhosis at the micro level
prevents the development of new fibrotic fibers
cleans the liver of dead cells
promotes liver tissue regeneration
prophylactic oncotransformation of liver cells

Mechanism of action
IMMUNE
INFLAMMATION
BIIRIN
BLOCKADE
INFLAMMATORY AND FIBROUS
CASCADE
CELL APOPTOSIS
PRODUCERS
Fibrous tissue
REGENERATION
LIVER
DISINTEGRATION
COLLAGEN FIBERS
And their phagocytosis
ACTIVATION OF REGULATORY MACROPHAGES THAT SYNTHESIZE COLLAGENASE
STRENGTHENING ANTI-VIRUS EFFICIENCY AT THE STAGE OF ETIOTROPIC TREATMENT

Clinical experience
Biirin helps to reduce the expression of TGF-β1 and provides the liver with the necessary conditions for the regression of fibrotic fibers.[1].
1.А.М.Печинка, А.С.Карданов. Роль антифибротической терапии в лечении хронических гепатитов. Новости медицины и фармации - № 11 (663) - 2018 - С. 6–8

Clinical experience
Biirin induces the activation of MMP-1 matrix metalloproteinase, a key antifibrotic factor in liver cirrhosis.[1].
1.А.М.Печинка, А.С.Карданов. Роль антифибротической терапии в лечении хронических гепатитов. Новости медицины и фармации - № 11 (663) - 2018 - С. 6–8

Towards full restoration
liver work the patient goes through 5 stages
the key of which is the anti-collagen phase.
During this phase are provided
necessary conditions for regeneration
liver tissue.
By inhibiting TGF-β1 and activating MMP-1
Biirin breaks the pathological cascade
fibrosis and gives rise to liver recovery.
BIIRIN: key moment