hit the road to begin traveling

drive someone up the (a) wall
to irritate or annoy someone; to make a person very angry or bored; to infuriate.
Example:
Her persistent nagging drove me up the wall.
My children always drive me up a wall when they are tired and in a bad mood.

travel light
to bring very few things with you when you go on a trip
Examples:
My new car has lots of cargo space, which is great for people like me who don’t travel light.
Everything is simpler when you travel light.

to throw someone under the bus
to reject or betray (someone); to treat as a scapegoat; to put out of favor or at a disadvantage
Examples:
1. Ruby Red, I didn't have time to do the business report, so I threw you under the bus and told the boss it was your job instead.
2. Every time the president gets in trouble, he'll throw another cabinet member under the bus.

(go down) a rocky road
(go through) a difficult period of time, have problems
Examples:
1.Bob has been going down quite a rocky road since his divorce.
2. Analysts predict a rocky road ahead for the economy.