Содержание
- 2. Key points of the lecture Graves' disease: definition, history, causes, symptoms and signs, taking diagnosis and
- 3. The main thyroid and parathyroid disorders include: Graves' disease Hypothyroidism Hashimoto’s thyroiditis Hypoparathyroidism
- 4. Graves' disease Graves' disease is an autoimmune disease of a thyroid. It most commonly affects the
- 5. History Graves' disease owes its name to the Irish doctor Robert James Graves, who described a
- 6. Epidemiology and causes Graves' disease affects up to 2% of the female population, sometimes appears after
- 7. Pathophysiology There appears to be a genetic predisposition for Graves' disease. Graves' disease is an autoimmune
- 8. Exophthalmos It`s protrusion of the eyeball from the orbit, caused by disease, especially hyperthyroidism, or injury.
- 9. Classical clinical features (triad) of Graves' disease Goiter is an enlarged thyroid gland and is of
- 10. Other main symptoms and signs Fatigue Weight loss with increased appetite Muscle weakness Non-pitting edema (pretibial
- 11. Graves' disease Symptoms
- 12. Gigantic goiter in woman 32 year old
- 13. Graves' ophthalmopathy Thyroid-associated ophthalmopathy is one of the most typical symptoms of Graves' disease. The ocular
- 14. Diagnosis Another sign of Graves' disease is hyperthyroidism – overproduction of the thyroid hormones T3 and
- 15. Treatment Treatment of Graves' disease includes antithyroid drugs which reduce the production of thyroid hormone, radioiodine
- 16. Antithyroid drugs The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and
- 17. Radioiodine Radioiodine (radioactive iodine-131) was developed in the early 1940s at the Mallinckrodt General Clinical Research
- 18. Surgery This modality is suitable for young patients and pregnant patients. Indications are: a large goitre
- 19. Hypothyroidism Hypothyroidism is the disease state in humans and in vertebrates caused by insufficient production of
- 20. Causes Iodine deficiency is the most common cause of hypothyroidism worldwide. In iodine-replete individuals hypothyroidism is
- 21. Early symptoms and signs in adults Poor muscle tone (muscle hypotonia) Fatigue Cold intolerance, increased sensitivity
- 22. Late symptoms Slow speech and a hoarse, breaking voice – deepening of the voice can also
- 23. Diagnostic testing To diagnose primary hypothyroidism, many doctors simply measure the amount of thyroid-stimulating hormone (TSH)
- 24. Hashimoto's thyroiditis Hashimoto's thyroiditis is an autoimmune disease in which the thyroid gland is gradually destroyed
- 25. Epidemiology This disorder is believed to be the most common cause of primary hypothyroidism in North
- 26. Causes The family history of thyroid disorders is common, with the HLA-DR5 gene most strongly implicated
- 27. Hashimoto’s thyroiditis histology Physiologically, antibodies against thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in
- 28. Symptoms and signs Symptoms of Hashimoto's thyroiditis include weight gain, depression, mania, sensitivity to heat and
- 29. Treatment Hypothyroidism caused by Hashimoto's Thyroiditis is treated with thyroid hormone replacement agents such as levothyroxine
- 30. Hypoparathyroidism In medicine (endocrinology), hypoparathyroidism is decreased function of the parathyroid glands, leading to decreased levels
- 31. Causes of the hypoparathyroidism Removal of or trauma to the parathyroid glands in thyroid surgery (thyroidectomy)
- 32. Signs and symptoms Tingling lips, fingers, and toes Muscle cramps Pain in the face, legs, and
- 33. Additional symptoms that may be associated with this disease include Painful menstruation Hand or foot spasms
- 34. Diagnosis Diagnosis is by measurement of calcium, serum albumin (for correction) and PTH in blood. PTH
- 35. Treatment Severe hypocalcemia, a potentially life-threatening condition, is treated as soon as possible with intravenous calcium
- 36. First aid In the event of a life-threatening attack of low calcium levels or tetany (prolonged
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