Malignant hyperthermia /pickled pig
MALIGNANT HYPERTHERMIA MH is a hypermetabolic syndrome involving skeletal muscle characterized by hyperthermia, tachycardia, tachypnea, increased oxygen consumption, cyanosis, cardiac dysrhythmias, metabolic acidosis, respiratory acidosis, muscle rigidity, unstable arterial blood pressure, and death. ETIOLOGY It is an inherited pharmacogenetic disorder of humans, swine, dogs, and horses MH is inherited as an autosomal recessive gene in swine but as an autosomal dominant gene in humans, horses, and dogs. Genetic mapping of the MH locus in pigs and humans placed it in the vicinity of the RYR1 gene , which encodes the sarcoplasmic reticulum ryanodine receptor (calcium release channel).