Слайд 5MORPHOLOGY
The trophozoites are 20-30 µm in diameter and contain a vesicular nucleus
![MORPHOLOGY The trophozoites are 20-30 µm in diameter and contain a vesicular](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-4.jpg)
with a central endosome, peripheral chromatin and radial achromatic fibrils (imparting a 'cart-wheel' appearance). The cysts are spherical measuring 10-15 µm in diameter and have 4 nuclei.
Слайд 7CYST MORPHOLOGY
Cysts are typically found in formed stool, whereas trophozoites are typically found
![CYST MORPHOLOGY Cysts are typically found in formed stool, whereas trophozoites are](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-6.jpg)
in diarrheal stool. Infection with Entamoeba histolytica (and E.dispar) occurs via ingestion of mature cysts from fecally contaminated food, water, or hands.
Слайд 11LIFE CYCLE
Infection by Entamoeba histolytica occurs by ingestion of mature cysts (2) in fecally
![LIFE CYCLE Infection by Entamoeba histolytica occurs by ingestion of mature cysts](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-10.jpg)
contaminated food, water, or hands. Excystation (3) occurs in the small intestine and trophozoites (4) are released, which migrate to the large intestine.
Слайд 14PATHOGENECITY
Entamoeba histolytica, a protozoan parasite, is the etiologic agent of amoebiasis in
![PATHOGENECITY Entamoeba histolytica, a protozoan parasite, is the etiologic agent of amoebiasis](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-13.jpg)
humans. It exists in two forms—the trophozoite which is the active, dividing form, and the cyst which is dormant and can survive for prolonged periods outside the host. In most infected individuals the trophozoites exist as commensals.
Слайд 15DISEASE
Entamoeba histolytica is an anaerobic parasitic amoebozoan, part of the genus Entamoeba.
![DISEASE Entamoeba histolytica is an anaerobic parasitic amoebozoan, part of the genus](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-14.jpg)
Predominantly infecting humans and other primates causing amoebiasis, E. histolytica is estimated to infect about 35-50 million people worldwide. E. histolytica infection is estimated to kill more than 55,000 people each year.
Слайд 16DIAGNOSIS
A single stool examination has a low sensitivity of detecting the parasite
![DIAGNOSIS A single stool examination has a low sensitivity of detecting the](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-15.jpg)
. The best diagnostic method is detection of E. histolytica antigen or DNA in stool . Clinical diagnosis of amebiasis is difficult because of the nonspecific nature of symptoms
Слайд 17TREATMENT
To treat invasive amebiasis, metronidazole (Flagyl, MetroGel, Noritate) is recommended even for amoebic liver
![TREATMENT To treat invasive amebiasis, metronidazole (Flagyl, MetroGel, Noritate) is recommended even](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-16.jpg)
abscesses (up to 10 cm sized abscesses). Tinidazole (Tindamax) is FDA approved for treatment of both intestinal or extraintestinal (invasive) amebiasis.
Слайд 18PREVENTION and CONTROL
Improved sanitation will help to reduce the liklihood of transmission. Travelers
![PREVENTION and CONTROL Improved sanitation will help to reduce the liklihood of](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/966109/slide-17.jpg)
to endemic areas can reduce the risk of infection by drinking bottled water, not using ice cubes in drinks, and washing fruits and vegetables with clean water (or by peeling them yourself).