Tolerance, autoimmunity, allogenicity

Tolerance, Autoimmunity, Allogenicity
(2nd part)
III- Autoimmunity
A – AID classification and examples
B – animal models
C – Why do AID occur?
D – Diagnosis, Treatments?
IV- Allogeneicity and transplantation tolerance
A – Concept and mechanism of Allogenicity and MLR
B – Classification & Mechanism of Graft rejection
C – GVHD
D – Biotherapies?

III - Autoimmunity

The causes of the disease outbreak are still unknown
7 % of population (still increasing)
Characteristics: evolutive, progression by surges
, environment

III- Autoimmunity
A - AID classification and examples

Wikipedia 2011
Hypersensibility
? Complement lysis
? Ag-Ab accumulation
? T cell-mediated Autoimmunity
? Agonists or bloquing Ab
T1D
Oophoritis
Prostatis
…
(lungs & Kidneys)
(RBCs)
(Platelets)
(Mother Abs cross Placenta)

Type II-V :
affects up to 2% of the female population, sometimes appears after childbirth, Hereditary factors are the major risk factor for the development of Graves disease, with "79% of the liability to the development of GD ... attributable to genetic factors”. Smoking and exposure to second-hand smoke is associated with the eye manifestations but not the thyroid manifestations.
This leads to an enlargment of the thyroid and very high levels of circulating thyroid hormones
The hormonal dysregulation induces heartbeat, muscle weakness, disturbed sleep, and irritability.

(Type II-V)

(SLE)

Mark Anderson, MD, PHD UCSF Diabetes Center

Production of autoantibodies