Tumor Irradiation

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Figure 2

Routes of Administration

Intravenous

Intranodal

Subcutaneous

Intradermal

Tumor Lysate

Whole tumor
mRNA extracts

Plasmacytoid DC

B cell

Immunogenic treatments

exosomes

Antigen types

HOCl oxidation

UV

Figure 2 Routes of Administration Intravenous Intranodal Subcutaneous Intradermal Tumor Lysate Whole
irradiation

Heat shock

hyperthermia

Principal APCs

Microneedle patches

3d synthetic scaffolds

Synthetic encapsulation

Routes of
administration

cDC1

cDC2

iDCs

macrophage

CD123+
CD11c-
CD303+
CD304+

CD123-
CD11c+
CD141+
Clec9A+

CD123-
CD11c+
CD1c+
Clec9A-

CD16-
CD11c+

CD19+
CD20+

liposome

Synthetic polymer
nsnoparticle

hydrogel

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Priming modalities

Personalized synthetic vaccine

Boosting

Synthetic vaccine

Synthetic vaccine

Synthetic vaccine

Standard of care/ in situ approaches

Radiotherapy
Chemotherapy
Cryoablation
Immunomodulation

Whole

Priming modalities Personalized synthetic vaccine Boosting Synthetic vaccine Synthetic vaccine Synthetic vaccine
tumor vaccine

Patient interrogation

*

Blood collection and tumor biopsy

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