Humoral Immunity or cellular immune response

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BM -Bursa - Thymus

BM -Bursa - Thymus

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Thymus gland

Bursa of Fabricius
Bone marrow

Then Enter

Thymus gland Bursa of Fabricius Bone marrow Then Enter

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B lymphocytes

T lymphocytes

T and B lymphocytes enter 2ry lymphoid organs (Spleen and

B lymphocytes T lymphocytes T and B lymphocytes enter 2ry lymphoid organs
lymph nodes) for proliferation and differentiation

Cellular Immunity or cellular immune response

Humoral Immunity or cellular immune response

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Cellular Immunity or cellular immune response is called Cell mediated Immunity or

Cellular Immunity or cellular immune response is called Cell mediated Immunity or
Cell mediated immune response

Humoral Immunity or Humoral immune response is called antibody mediated Immunity or antibody mediated immune response

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Natural killer (NK) cells are also known as large granular lymphocytes (LGL)

Natural killer (NK) cells are also known as large granular lymphocytes (LGL)
because they resemble lymphocytes in their morphology, except that they are slightly larger and have numerous granules. NK cells are capable of killing virus infected and malignant target cells by perforin and Granzymes (process called Apoptosis)

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Ab production

Ab production

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Ig = Immunoglobulin Structure

Ig = Immunoglobulin Structure

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Structural Regions

Structural Regions

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III. BASIC STRUCTURE OF IMMUNOGLOBULINS

Although different immunoglobulins can differ structurally they

III. BASIC STRUCTURE OF IMMUNOGLOBULINS Although different immunoglobulins can differ structurally they
all are built from the same basic unit.

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Ab Structure

Ab Structure

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A. Heavy and Light Chains

All immunoglobulins have a four chain structure

A. Heavy and Light Chains All immunoglobulins have a four chain structure
as their basic unit. They are composed of two identical light chains and two identical heavy chains
B. Disulfide bonds

1. The heavy and light chains and the two heavy chains are held together by inter-chain disulfide bonds interactions.

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C. Variable (V) and Constant (C) Regions

both the heavy and

C. Variable (V) and Constant (C) Regions both the heavy and light
light chain could be divided into two regions based on variability in the amino acid sequences:
Light Chain - VL and CL
2. Heavy Chain - VH and CH

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Types of T cells
T- Helper (CD4 T cells)
Helps T-cytotoxic
Helps B cells
Helps NK

Types of T cells T- Helper (CD4 T cells) Helps T-cytotoxic Helps
cells
T- Cytotoxic (CD8 T cells)
T- Regulatory
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