Содержание
- 2. UCSC Genome Browser
- 3. UCSC Genome Browser
- 4. UCSC Genome Browser
- 5. UCSC Genome Browser
- 6. UCSC Genome Browser
- 7. Complete human genome
- 8. Transposable Elements 45% of the human genome is occupied by transposons and transposon-like repetitive elements. Barbara
- 9. Схожесть с ретровирусами Retrovirus reverse transcripiton http://www.youtube.com/watch?v=eS1GODinO8w Class II Class I – retrotransposons (via RNA intermediate)
- 13. Active Non-Active
- 14. First Layer of Genome Annotation
- 15. Epigenetics
- 16. Second Layer of Genome Annotation
- 17. Second Layer of Genome Annotation
- 18. Second Layer of Genome Annotation
- 19. Second Layer of Genome Annotation
- 20. Second Layer of Genome Annotation
- 21. Third Layer of Genome Annotation
- 22. Data Accumulation
- 23. ENCODE: Encyclopedia of DNA Elements
- 24. Digital Universe Like the Physical Universe the Digital Universe is also expanding but much faster doubling
- 25. Digital Universe Data Universe Will Expand To 44 Trillion GBs By 2020
- 26. Что делать?
- 27. Что получилось? (Success Stories)
- 28. СКРЫТЫЕ ЦЕПИ МАРКОВА
- 29. Gene Prediction
- 30. E0 E1 E2 E2 E1 E0 N P Eterm P Einit polyA 5’ UTR I0 I1
- 31. Promoter prediction Hidden Markov model with six interpolated Markov chain submodels upstream 1 and 2, TATA
- 32. predict tissue-dependent changes in alternative splicing for thousands of exons. 1,014 features: known motifs, new motifs,
- 33. Genome intrinsic organization can explain ,50% of the in vivo nucleosome positions Probabilistic nucleosome–DNA interaction model
- 35. Schematic overview of epigenetic regulatory mechanisms. Yonggang Zhou et al. Circ Res. 2011;109:1067-1081 Copyright © American
- 36. Random Forest model predicts cancer mutation densities from epigenomic mark ups
- 38. We have many experimental genome-wide annotations Question 1: Are different annottaions correlated? To what extent? Question
- 39. Annotations under different conditions
- 40. Как много данных? Roadmap Epigenomics ~ 3 000 полногеномных данных ENCODE Encyclopedia of Genomic Elements ~
- 41. Открытые вопросы Какие участки кода работают одновременно? Как переключать режимы работы клетки? Как перепрограммируется код для
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