Слайд 2Phylogenetic disorders of respiratory system
Introduction
Abnormalities of the respiratory system include not only
![Phylogenetic disorders of respiratory system Introduction Abnormalities of the respiratory system include](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/1022392/slide-1.jpg)
lung development but also the upper respiratory tract, the supporting musculoskeletal system and the vascular and neural system. In addition, some respiratory problems arise from prematurity of birth or difficulty with the birth process itself.
The functional part of the respiratory system, the alveoli, continue to develop the postnatal period and through childhood
Слайд 3Major Disorders
Cleft Laryngeal-tracheo- oesophageal cleft
A rare foregut abnormality allowing digestive tract and
![Major Disorders Cleft Laryngeal-tracheo- oesophageal cleft A rare foregut abnormality allowing digestive](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/1022392/slide-2.jpg)
the airway to communicate causing chronic cough, aspiration and respiratory distress.
Слайд 5Lobar Emphysema
There is an overinflated left upper lobeThere is a collapsed lower
![Lobar Emphysema There is an overinflated left upper lobeThere is a collapsed](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/1022392/slide-4.jpg)
lobe The left lung is herniating across the mediastinum
Слайд 7Congenital Diaphragmatic hernea
Failure of the pleuroperitoneal foramen (foramen of Bochdalek) to close
![Congenital Diaphragmatic hernea Failure of the pleuroperitoneal foramen (foramen of Bochdalek) to](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/1022392/slide-6.jpg)
allows viscera into thorax, most common (80-85%) on the left side of diaphragm. Intestine, stomach or spleen can enter the pleural cavity, compressing the lung.
Слайд 9Azygos Lobe
The right lung upper lobe expands either side of the posterior
![Azygos Lobe The right lung upper lobe expands either side of the](/_ipx/f_webp&q_80&fit_contain&s_1440x1080/imagesDir/jpg/1022392/slide-8.jpg)
cardinal. There is also some course variability of the phrenic nerve in the presence of an azygos lobe
Слайд 11Congenital Laryngeal Web
Laryngeal abnormality due to embryonic (week 10) incomplete recanalization of
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the laryngotracheal tube during the fetal period. Rare abnormality occuring mainly at the level of the vocal folds (glottis).
Слайд 13Meconium Aspiration Syndrome
Meconium is the gastrointestinal contents that accumulate in the intestines
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during the fetal period. Fetal stress in the third trimester, prior to/at/ or during parturition (birth) can lead to premature meconium discharge into the amniotic fluid and sunsequent ingestion by the fetus and damage to respiratory function. Damage to placental vessels meconium myonecrosis may also occur. meconium is formed from gut and associated organ secretions as well as cells and debris
from the swallowed amniotic fluid. Meconium accumulates during the fetal period in the large intestine (bowel). It can be described as being a generally dark colour (green black) , sticky and odourless. Normally this meconium is defaecated
(passed) postnatally over the first 48 hours and then transitional stools from day 4.
Слайд 15Surfactant metabolism disorder
Surfactant metabolism dysfunction is a condition where pulmonary surfactant is
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insufficient for adequate respiration. Surface tension at the liquid-air interphase in the alveoli makes the air sacs prone to collapsing post expiration.
Слайд 16Bronchopulmonary dysplasia
A chronic lung disease which can occur following premature birth and
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related lung injury. The definition of bronchopulmonary dysplasia (BPD) has in recent years changed from a severe lung injury and associated
repair, to more of a disruption of lung growth in older infants. Most infants who develop BPD are born more
than 10 weeks before their due dates, weigh less than 1,000 grams (about 2 pounds) at birth, and have breathing problems. Infections that occur before or shortly after birth also can contribute to BPD.
Слайд 18Cystic fibrosis
Fibrosis (CF) is a serious genetic disease due to abnormal chloride
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channel synthesis cystic fibrosis transmembrane conductance regulator, CFTR), the impact occurs postnatally. Mucus accumulates mainly in the passages of the lungs and in the pancreas.