Medical academy named after s.i georgievsky of vernadsky CFU

GENEALOGICAL
METHOD
Medical Genealogy is the study of families, family lineages and medical family history.
Information about a family is obtained by oral interviews
.

Examples: 1. By a clinical
geneticist
2. physician or a
genetic couselor from medical and historical records, (previous) genetic analysis, and other relevant sources.

Genealogy is utilized in basic research of genetic rules governing transmission of a trait and, in clinical (medical) genetics, for clinical consulting practice at follow-up of inheritance of various traits.

WHAT IS THE MEANING OF
GENEALOGICAL
1 : an account of the descent of a person, family, or group from an ancestor or from older forms.
2 : regular descent of a person, family, or group of organisms from a progenitor or older form : pedigree.
3 : the study of family ancestral lines.

PEDIGREE ANALYSIS
This is a graphical recording of kinship relations between persons in individual generations.
It represents the foundation of genealogical method and provides basic informaion about the occurrence of chosen trait/phenotype.

PEDIGREE SYMBOL TABLE

PEDIGREE SYMBOL TABLE

NUMBERING
OF INDIVIDUAL
IN PEDIGREE

WHAT IS PROBAND
The person providing the information for construction of pedigree and being interested in evaluation/estimate of the probability (risk) of recurrence of the trait; in the pedigree, this person is labeled with an arrow

GENEALOGY ANALYSIS AS METHOD OF RESEARCH
From biological point of view, genealogy is considered as one of methods of genetic research. It resides in a selection of families with suitable types of crossing.
Afterwards, this genealogy material is subjected to logical analysis

In individual families, the effort is made to explain the transmission of traits by schedules used in experimental phenogenetics.
For examination of the type of genetic determination in genealogy, many statistical methods (and now computer programs) have been developed enabling investigation of the ratios, the penetrance of followed gene, and estimates of the heritability using a collection (databases) of pedigrees.